ACCT 210 Lecture Notes - Lecture 36: Polysaccharide, Thymus, Dendritic Cell
12 Jul 2020
School
Department
Course
Professor
Document Summary
Subunit: approaches undertaken to enhance immunogenicity of vaccines. Carrier systems e. g. viral vectors and dendritic cells. The initial response to a pathogen is called the primary immune response: eradiate pathogen first time, contraction of t and b cells following clearance of pathogen, appearance of memory cells. Memory cd4 and cd8 cells: can be subdivided into two subtypes on the basis of chemokine receptor ccr7, effector memory t cells, effector memory t cells, ccr7 negative. Secondary antibody responses are dominated by class-switched b cells. They have a higher affinity for that pathogen. Variolation: transmission (usually injection) of a small amount of the dangerous pathogen to induce a robust immune response upon secondary encounter with the same pathogen: risk of viral load and aggressive infection leading to death. The pox: smallpox, two types variola major (30-35% mortality) and variola minor (1% mortality, 12 day incubation before symptoms, first wave causes cell lysis and enters bloodstream.
