BIOL 031 Lecture Notes - Lecture 4: Adenylyl Cyclase, Aquaporin 2, Posterior Pituitary

• School: College of The Sequoias
• Department: Biology (BIOL)
• Course: BIOL 031
• Professor: Moore

Document Summary

Na+ + cl- ions reabsorbed h2o follows by osmosis. Solutes in tubular lumen local osmolarity in tubular fluid / local. Na+ tubular lumen pt isf. H2o follows na+ + other ions out of tubular lumen. Adh stimulates insertion of aqp2 into apical mem of cd cells cell signaling. Adh from posterior pituitary binds receptor on basolateral mem. Pka phosphorylates proteins that rate of fusion of vesicles w aqp2 into. H2o diffuses out of tubular lumen through aqp2 in apical mem. H2o diffuses out of cd cell through aqp3 + aqp4 in basolateral mem apical mem. H2o flows out by diffusion + reabsorbed by body. Fluid in descending limb osmolarity = isf osmolarity. [filtrate] becomes more dilute going up ascending limb. Transport of ions out h2o can"t follow bc impermeable. Active reabsorption of ions in ascending limb. No active transport of ions out of ascending limb into isf. No gradient established can"t concentrate medullary fluid h2o stays in tubule h2o excreted.