BIOL 031 Lecture Notes - Lecture 19: Antigen-Presenting Cell, Cytotoxic T Cell, Cell-Mediated Immunity

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A pathogen or extracellular antigen is phagocytized by antigen-presenting cell (dendritic cell here) and placed into a vesicle (phagosome). Ingested pathogens are then digested by lysosomes in the cytoplasm of the cell to extract the antigens of the pathogen. The antigens then bind with mhc proteins and and then the complex (the antigen and. Co-stimulation is the additional physical and chemical signals required for full lymphocyte activation. Co-stimulation occurs through the binding of cell surface molecules: Class i mhc: these macrophages that are antigen-presenting cells bind to the receptor on the receptor of the cd8+ cell (cytotoxic t cell). This is the first point of contact and is not enough. Located on the surface of the cd8+ cell is the cd8 protein. This cd8 protein binds to the mch and antigen complex on the infected cell. The third point of contact is between the.

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