BIOL 031 Lecture Notes - Lecture 9: Hydroxylation, Triamterene, Calcitriol

• School: College of The Sequoias
• Department: Biology (BIOL)
• Course: BIOL 031
• Professor: carey

Document Summary

Not part of the learning objective, so i"ll just put the picture he had. Reabsorption of amino acids and small peptides. Transporters are specific for different groups of amino acids. Mutations of these transporters impair reabsorption of these amino acids and can cause diseases like cystinuria. Excess cystine in the urine leads to kidney stonesouch. Small peptides like hormones (insulin, growth hormone, etc) and microglobulin are taken up through absorptive endocytosis. Caught by proteins called cubilin and megalin. Degraded in acidified endocytic vesicles or lysosomes. Acidification depends on a proton pump (h+-atpase) and a. Cl- channel impaired acidification of these endocytic vesicles causes low molecular weight proteinuria (dent"s disease) and kidney stones. Activation of vitamin d occurs in the pt through hydroxylation of the hydroxy vitamin d produced by the liver. Kidney produces calcitriol, which is a potent stimulator of intestinal calcium reabsorption and is critical for bone metabolism. Major divisions and functions of the loop of henle.