BIOL 031 Lecture Notes - Lecture 19: Anuria, Sodium-Potassium Alloy, Acidosis

• School: College of The Sequoias
• Department: Biology (BIOL)
• Course: BIOL 031
• Professor: carey

Document Summary

Physiological requirements for diluting and concentrating urine. A 70 kg human must excrete about 600mosm of solute per day. The minimum amount of urine to do this should be . 5l/day. Functional v2 vasopressin receptors (v2r) in the collecting duct. Functional aquaporin-2 water channels in the collecting duct. Adequate delivery of nacl to the thick ascending limb. Separation of salt and water by the thick ascending limb. We have to find this by measuring the total osmolal clearance: Cosm = uosm * v / posm. Uosm is urine osmolality and posm is the measured plasma osmolality. So, we think of all urine as one part containing all solute (cosm) and one part containing all water (ch2o) If ch2o is positive, it means that some solute free water is being excreted. If it"s negative value that means that solute-free water is being retained.