BIOL 031 Lecture Notes - Lecture 30: Phospholipase A2, Proteinuria, Hemostasis
22 Dec 2020
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Document Summary
Nephrotic patients are prone to developing intravascular clots because there are urinary losses of anticoagulant proteins (antithrombin iii and. Lose proteins involved with immunity such as. Alternative complement pathway factors b and d. The edema causes abdominal ascites which is a great media for bacteria to grow. A lot of vitamin d (and calcitriol) loss in urine. Thyroid binding globulin is lost in urine but not very clinically significant in nephrotic syndrome. Iron-binding proteins may be lost in the urine, may lead to severe anemia (but anemia is uncommon) Decreased buffering capacity, decreased tissue perfusion, biochemical effects on metabolism, effects on drug metabolism/transport/efficacy. Podocytopathy - diseases characterized by dysfunction of podocyte (effacement) A reversible disorder of podocyte function that results in massive proteinuria but little/no abnormality apparent by light microscopy. Presented with anasarca (edema everywhere) usually in children (with a genetic predisposition) Triggered by an immune stimulus (uri, allergy, bee sting) Cd80 binds to slit diaphragms interferes w/ function.
