BIO 203 Lecture Notes - Lecture 1: Bile Acid, Peritubular Capillaries, Oncotic Pressure

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For solutes that move by epithelial transport, their [] or electrochemical gradient determine their transport mechanism. Solutes moving down their gradient use open leak channels or facilitated diffusion carriers to cross membrane; molecules use active transport to move against their gradient. Paracellular pathway, substances pass through cell-cell jxn btwn two adjacent cells. Which route a solute takes depends on permeability of epithelial jxns and on the electrochemical gradient for solute. Active transport of na; active reabsorption of na is primary driving force for renal reabsorption. Filtrate entering proximal tubule is similar in ion composition to plasma, with a higher [na] than in cells. Na in filtrate can enter tubule cells passively by moving down electrochemical gradient. Apical movement of na uses symports, antiports, or open leak channels. In proximal tubule, the na-h exchanger (nhe) plays major role in na reabsorption as does apical epithelial na channel (enac)

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