HSCI 301 Lecture Notes - Lecture 20: Nephrotoxicity, Cell Membrane, Mycobacterium

• School: Drexel University
• Department: Health Sciences
• Course: HSCI 301
• Professor: William D' Andrea

Document Summary

Chapter 39: protein synthesis inhibitors: understand/review the function of a ribosome within a cell, know the structural differences between the prokaryotic (bacterial) ribosome and the mammalian (eukaryotic) ribosome, and associate this to the mechanism of action of protein. Ribosome: synthesizes proteins in the cell (by linking amino acids together from. Rna: smaller in prokaryotes (aka bacteria): 70s (30s + 50s, larger in eukaryotes: 80s (40s + 60s) Protein synthesis inhibitors have selective toxicity by acting on prokaryotic ribosome units that are different sizes than ours so it kills them and not us : tetracycline class - protein synthesis inhibitors; Ma(cid:272)rolide"s: (cid:271)i(cid:374)ds to 50s su(cid:271)u(cid:374)it = stops tra(cid:374)slo(cid:272)atio(cid:374) = stops protei(cid:374) s(cid:455)(cid:374)thesis: broad spectrum (gram +, gram -, chlamydia, & mycoplasma, drugs, erythromycin, azithromycin (zithromax, z-pack, clarithromycin (biaxin) Indications for: upper & lower respiratory infections (gram -, skin infections (staph gram +, otitis media, chlamydia, for the oxazolidinone: linezolid (zyvox)