HSCI 301 Lecture Notes - Lecture 4: Endometrial Hyperplasia, Bone Resorption, Secondary Sex Characteristic

• School: Drexel University
• Department: Health Sciences
• Course: HSCI 301
• Professor: William D' Andrea

Document Summary

Estrogen: cholesterol > progesterone > androstenedione > estrone > estradiol, background: Increases vaginal lubrication: promotes secondary sex characteristics, decelerates growth after puberty, reduces muscle mass, stimulates endometrial/uterine growth, promotes thickening of vaginal wall during period, reduces bone resorption and increases bone formation. Increases hepatic synthesis of clotting factors 2, 7, 9, 10 plasminogen. Increases platelet adhesiveness: reduces anti-thrombin 3 effects, helps maintain body temp, thought that withdrawal of estrogen causes increased fsh & lh = effe(cid:272)ts (cid:271)od(cid:455) te(cid:373)perature the i(cid:374)(cid:272)reased fsh & lh = (cid:448)asodilatio(cid:374) = increases blood flow to skin = raises temperature/hot flash: thought that estrogen therapy puts hypothalamus back in control of ne secretion = decreases frequency of hot flashes. Fsh = inhibits follicular development = inhibits estradiol from rising = inhibits estrogen/lh surge needed for ovulation: progestogen contraception, low dose: norethindrone (ortho-micronor) (relies on progestogenic effect of thickening of cervical mucus to kill sperm) Intermediate dose: cerazette (allows for some follicular development: high dose: medroxyprogesterone (depo-