NFS 203 Lecture Notes - Lecture 3: Intrauterine Growth Restriction, Hypogonadism, Anemia
Document Summary
Fertility disrupted by metabolic & hormonal changes from high/low levels of body fat. Abnormal metabolic and health indicators (chronic inflammation and oxidative stress) Increases risk of cdv and type 2 diabetes. Obesity w/ high levels of central body fat. Gene variants influence glucose utilization, inflammation and source of fat stores. Diet modifications (antioxidant rich, low fat dairy) Decrease oxidative stress with whole grains, colorful produce, limited sugar beverages and food. Excess intra abdominal fat related to: insulin resistance, inflammation, oxidative stress, and metabolic syndrome. Not everyone w/ high or low body fat are at risk of fertility issues if you dont have metabolic disorders. Obese person can be metabolically healthy (no hbp, inflammation, oxidative stress) while a normal weight person w/ extra abdominal fat can have metabolic disorder. Weight loss is the first choice of obese infertility treatment. Bariatric surgery lowers risk of pregnancy diabetes and hypertension but increases risk of deficiencies.