BIOSC-101 Lecture Notes - Lecture 14: Acylation, Van Der Waals Force, Cytosol
26 Aug 2020
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Document Summary
Membranes proteins in terms of their functions: Integral membrane protein (spans the bilayer with 3 segments) Exoplasmic surfaces (hydrophobic amino acids may interact with polar heads) Hydrophobic region in the middle: a-helix, forms hydrophobic and van der waals interactions with the membrane. Have a hydrophobic segment embedded in the leaflet which binds covalently to one or more lipid molecules. Bound indirectly by integral or lipid anchored membrane protein"s or directly by interactions with lipid head groups. They may interact with cytoskeleton or extracellular matrix (ecm) It determines the cell shape, mechanical properties, and facilitates communication from the exterior to the interior of the cell. Proteins exhibit specific orientation with respect to cytoplasmic and exoplasmic faces. Single a-helix (with hydrophobic amino acids) and charged polar parts near cytoplasmic face to anchor in the membrane. Largest group of integral mp"s in eukaryotes. They respond to hormones, neurotransmitters, and local mediators. Hydrophilic core for transport of water, glycerol, hydrophilic solutes, across the membranes.
