BIOSC-116 Lecture Notes - Lecture 23: Atp Hydrolysis, Glutamic Acid, Glutamine
9 Oct 2020
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This energy, the potential energy, is mostly in its phosphate groups since the phosphates have negative charges that repel each other. The breakdown of atp is spontaneous and is also the hydrolysis of atp. Once the phosphate is released the negative repulsion is relieved and this spontaneous reaction releases large amount of free energy. Atp + h2o adp + pi , pi is an inorganic phosphate ( g= -7. 9 kcal/mol) Adp can be further broken down to amp (monophosphate) but it won"t release as much free energy. In order for atp hydrolysis to be linked to an endergonic reaction without the energy being wasted in such forms as heat: Energy coupling: when atp hydrolysis is brought in close contact with the reactant molecule of the endergonic reaction. The enzyme associated with this has a binding spot for the atp and the reactant and when the hydrolysis occurs the inorganic phosphate is bonded to the reactant.
