PSYCH-200 Lecture Notes - Lecture 25: Muscle Tone, Synuclein, Idiopathy
8 Dec 2020
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Disorder that is part of a larger continuum. Synucleinopathies (as a group)- protein that creates problem is synuclein. Dlb: dementia lewy bodies, cognitive and personality inabilities. Idiopathic: unknown cause, not directly related to anything. Less than 5%, genetic influence (inherited/family) generation to generation. Stroke, tumor, head injury, clear event, aids, infections. Late 50s/early 60s, earlier for genetic group (typically 40s) More men than women, typically long lifespans after diagnosis (10-20 years) Tremor at rest: most likely when not doing anything purposeful. Still, difficult to move rigid muscle tone, issues bending joints. Brady kinesia: slow movement, careful movements, planning before they do it. Dopamine targeted cells; areas also use dopamine to control and organize muscle movement. Give extra dopamine to fix lack of. Dopamine too large to cross barrier that protects brain. L-dopa: dopamine precursor; chemical that enters brain, turning chemical into dopamine. Produces dopamine in whole brain, instead of just one portion. Making brain try to adjust to new chemical.
