BIOLOGY 20 Lecture Notes - Lecture 29: Inferior Nasal Concha, Chromatin, Vasoconstriction

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24 Dec 2020
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Lipid soluble hormones diffuse through cell membrane. Steroids: affect dna transcription rate and protein synthesis, change synthesis of enzyme and structural proteins affecting cell"s metabolic activity and structure. Thyroid hormones: bind to receptors on mitochondria, affecting energy production, bin to receptors in nucleus, affecting cell"s metabolic activity and structure. Hormones stimulate only those cells that have receptors for them. Receptors are protein or glycoprotein molecules: on a cell plasma membrane, in the cytoplasm or in the nucleus. Receptors act like switches turning on metabolic pathways when hormone binds to them. Usually each target cells has a few thousand receptors for a given hormone. Receptor hormone interactions exhibit specificity and saturation. Saturated when all receptor molecules are occupied by hormone molecules. Thyroid hormone enters target cell by diffusion mostly at t4 with little metabolic effect. Within target cell, t4 is converted to more potent t3. T3 enters target cells and binds to receptors in chromatin activating gene transcription.

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