BIOL 142 Lecture Notes - Lecture 8: Model Organism, Chromosome, Y Chromosome
Biology 142- Lecture 8- Linkage
Linkage
• Some genes don’t follow Mendel’s Principles
o Genes on the same chromosome cannot segregate independently, and they
follow their own characteristic pattern of inheritance
• Linked genes are to alleles on the same chromosome
Thomas Hunt Morgan’s Experiments
• Morgan used fruit flies as a model organism for genetic crossings
• Wild type= most common phenotype for each trait
• Mutant= not as common phenotype for each trait
• Morgan crossed male wild type fruit flies and female mutant fruit flies
o From this cross, he discovered x-linked inheritance
• X-linked inheritance
o Females have two X chromosomes (XX), and males have one X and one Y
chromosome (XY)
▪ Males are hemizygous
o The gene is only on the X chromosome, the Y chromosome cannot carry an allele
of this gene
o The Y chromosome cannot carry the allele of this gene because the Y
chromosome is smaller than X
▪ The genes that can be present on Y are very limited
o X-linked diseases would impact males more than females because they only have
one copy of the gene
▪ Meaning: if the carry the allele for the disease, they will have it
Reciprocal Cross
• A reciprocal cross is used to test and see if the trait in question is x-linked
• A reciprocal cross happens in two steps
o If you have two genotypes A and B: First, you cross a genotype A male with
genotype B female. Second, you cross a genotype B male with genotype A
female
• Example: You want to see if eye color is a sex-linked trait for fruit flies, where W=red
eyes and w=white eyes
o First cross:
Female
Male
XW XW
XwY