BIOL 336 Lecture Notes - Lecture 11: Exocytosis, Hydrophile, Golgi Apparatus
10 Aug 2016
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Lecture 11 - endocrinology iii: peptide and protein hormones. Be able to: describe the synthesis, secretion & transport of the the peptide and protein hormones. Remember that there are three major classes of endocrine hormones: amines, peptides and proteins, steroids, *this lecture focuses on the peptides and proteins. Peptide and protein hormones, are first made as large, inactive preprohormones. Preprohormones include additional amino acid sequences not found in the mature, final forms of these hormones. These amino acids make up signal copies of the hormone, and additional peptide fragments must be cut off from the preprohormone to form a final, biologically active hormone. fragments. The signal sequence + peptide sequences, one or more. Ex: insulin first originates as a preproinsulin form. It is cleaved and cut to form proinsulin. The part that is cleaved off is called the signal sequence/signal peptide. Prosinsulin is still not the biologically active form of insulin.
