HLTH 220 Lecture Notes - Lecture 15: Cirrhosis, Muscle Contraction, National Health And Nutrition Examination Survey
6 Dec 2016
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Some alcohol ingested is not bioavailable first pass metabolism . In the stomach some alcohol is metabolized by the enzyme alcohol dehydrogenase before diffusing into the gastric cells. Women have 20-30% less alcohol dehydrogenase in the stomach than men, so about. ~ more alcohol is absorbed into the bloodstream. First pass metabolism is lower in individuals who abuse alcohol, especially women (=higher bac) The major factor governing the absorption rate of alcohol is whether it is consumed on an empty stomach or with food. Prevents direct contact with gastric mucosa, decreases passive diffusion. Alcohol provides 7 kcal of energy per gram. Alcohol can"t be stored and remains in the body until metabolized/eliminated. Alcohol is oxidized preferentially over other nutrients. The major enzyme systems responsible for alcohol metabolism are present in the highest concentrations in the liver: alcohol dehydrogenase (adh, microsomal/cytochrome p 450-dependent ethanol-oxidizing system.
