NBB 201 Lecture Notes - Lecture 8: Congenital Adrenal Hyperplasia, Testis Determining Factor, Vocal Folds
27 Feb 2019
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Document Summary
Steroids (natural: four-ringed skeleton is modified to make all steroids, all are made from cholesterol. Include - cortisol (stress hormone), estrogen, progesterone, testosterone: gonadal steroids shape some sex differences, steroid biosynthesis - progesterone can be transformed to testosterone - modified shapes, hormone action. Fat-soluble, inside cytoplasm they combine with receptor complexes which combines with dna to turn on genes: testosterone - cells of vocal cords, the vocal cords lengthened because genes are turned on. Internal reproductive organs: undifferentiated: primordial state includes mullerian (female)& wolffian ducts (male) plus a pair of generic gonads. Some xx babies are born with uncertain sex assignment, ambiguous genitalia: causes, congenital adrenal hyperplasia - diversion of progesterone into pathway to testosterone, progestogen rx in pregnancy, old practice: Freud said "idea of gender in the mind is shaped by the family, society after birth" Surgery: hormone treatment, cah: causes and consequences. Steroid 21-ohase deficiency - can"t get turned into progesterone, has to go into become testosterone, aromatization.
