NBB 302 Lecture Notes - Lecture 10: Protein Synthesis Inhibitor, Post-Translational Modification, Anisomycin

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 302
• Professor: Gillian Hue

Document Summary

Memory consolidation: e(cid:454)plicit (cid:373)e(cid:373)ories are (cid:374)ot i(cid:374)sta(cid:374)teousl(cid:455) . (cid:894)? (cid:895, there"s cellular and systems consolidation. Cellular - happens at the level of the synapse within changes of minutes: short term memory that requires post-translational modifications, post-translational modification: methylation or phosphorylation, long-term memory requires gene expression. Classical view of consolidation: memories consolidate over time only once, thus from its initial fragile state becomes stable and insensitive to disruption, from graphical depiction of how memory works. In short term memory (stm), there"s a steep pike for consolidation. Learn to associate tone with shock and measure freezing behavior. Either acsf or psi (protein synthesis inhibitor, anisomycin) Graph 1: on test 2 - 48 hours later: differentiating between strong and weak memory. Has to do with the number of trials it takes for the mouse to learn. Have they repeated these studies in the hippocampus: normally, the amygdala is the one that is active during fear conditioning, hippocampus is important for contextual learning.