NBB 301 Lecture 12: lecture 12 notes

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 301
• Professor: Frenzel Kristen

Document Summary

"tug-of-war" b/w epsp and ipsp: epp drives depolarization --> activations v. g. Na to cause an ap --> ca release in muscle. To take it out, you must depolarize membrane: gating needs ligand and depolarization, nmda receptors and mg, physiological: Erev = 0: mg present -- blocking channel at -60 mv, experimental: No mg present: two flavors of glutamate receptors at the synapse. Which receptors are participating in the currents seen: voltage clamp experiments. Use nmda receptor antagonist apv to isolate currents due to ampa/kainate v. At each voltage, there are two experimental data, the currents + or - apv: at -80 mv --- fast inward current w/ and w/o apv. Nmda receptor has no influence at this membrane potential due to mg block: at -40 mv , the nmda still has mg blocking it so its prop of current is less.