PCB 4594 Lecture Notes - Lecture 10: Paraxial Mesoderm, Notch Signaling Pathway, Neurotrophin
Lateral plate Mesoderm
Gives rise to heart, blood vessels, blood cells, lining of body cavities, and pelvic and limb skeletal
components.
True or False.
Circulatory system and heart was the first to develop in vertebrates
TRUE
What are the 2 different tissues that somites can form?
Sclerotome and dermomyotome
Dermomyotome dermatome
Dorsal dermis and muscle
Dermatome
Forms dorsal dermis tissue.
Induced by Neurotrophin 3 from dorsal neural tube.
What are the transcription factors for the paraxial mesoderm?
Noggin, FoxC1, FoxC2
-crucial to somite formation. Don't have them, don't have somites
What is the BMP-Inhibitor that specifies germ tissue from the paraxial mesoderm?
Noggin
The Notch signaling pathway regulated expression of which TF?
Hes (hairy)
Fringe
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