PCB 4594 Lecture Notes - Lecture 11: Kidney Development, Sox9, Leydig Cell

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18 Jun 2018

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Myocytes

Muscle cells used in skeletal muscle development

What are the 2 main components of kidney development?

Nephritic duct

Nephrogenic mesoderm

What are some important genes needed for the development of the kidney?

GDNF & RET

FGFR1 (loss) = complete absence of kidney

Mindbomb = part of Notch, crucial n kidney development

Differentiation in Males

SRY & SOX9

-expressed in Sertoli cells

Leydig cells expressed only if SRY & SOX9 are present

-expressed testosterone

Differentiation in Females

SRY not present so WNT and FOX12 are made.

-thecal cells are made that express estrogen

Hematopoiesis

Formation of blood

Primitive Hematopoiesis

Occurs early in development

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