PCB 2061L Lecture Notes - Lecture 4: Pylorus, Gastric Mucosa, Gastrin
Document Summary
Chyme (mechanical digestion in the presence of gastric acid) Controlled rate of passage and quality of digestion of food to duodenum. The mucosa and pits are covered by columnar epithelium. Epithelial cells produce mucus which protects the epithelium against auto-digestion. Glands in the body and the fundus are elongated and contain 3 types of cells: Chief cells in body/fundus, produce pepsinogen parietal cells in body/fundus, produce hcl and the intrinsic factor for vitb12 absorption in the ileum. Gastrin is produced by g cells mainly in pyloric antrum stimulate acid secretion and growth of parietal cells. Gastrin secretion by non-beta cells of the pancreas (multiple ulcers in stomach). Tumor of non-beta cells of pancreas (in pancreas) the tumor cells secrete a substance similar to gastrin, which increases gastrin which then increases hcl secretion. Irregular pancreatic enzymes which affect the digestion and absorption of carbs, proteins and lipids.
