PCB 4232 Lecture Notes - Lecture 2: Nuclear Pore, Subtypes Of Hiv, Integrase
18 Dec 2016
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You can inactivate a virus by treating it with formaldehyde, chlorine, heat, Hiv-1 has monp groups m = major, then o (cid:523)1%(cid:524) and np (cid:523)really small(cid:524) Pol = rt, protease, and integrase (enzymes to replicate (rna polymerase)) Hiv enters by gp120 binding cd4 then ccr5 and gp41 darts out and pierces membrane to enter. They undergo rapid microtubule movement towards nuclear compartment. When getting close to nucleus they go from microtubules to actin filaments. Then integrace brings it inside host cell chromatin. Dna is integrated into cells dna by integrase. Virus encoded proteases cut enzyme molecules and capsid proteins then sections capsid proteins. Macrophages express cell-surface receptors that stimulate phagocytosis and intracellular killing of pathogens. Most infections agents activate innate immune system and induce an inflammatory response. Cytokine - protein secreted by cells and affecting behavior of nearby cell bearing appropriate receptor. Chemokine secreted small molecular weight proteins that act as chemoattractants.
