PCB 4232 Lecture Notes - Lecture 1: Lymphatic Vessel, Lymph Node, Mucosa-Associated Lymphoid Tissue
18 Dec 2016
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Document Summary
Afferent lymphatic vessels drain fluid from tissue carry pathogen and antigen. Malt most pthogens enter body thru mucosal surfaces bearing cells. Lymph leaves by the efferent lymphatic vessels mucosa associated lymphoid tissue -> malt has galt (gut associated lymphoid tissue) which includes tonsils, adenoids, appendix, and peyer"s patches. Peyers patches (microfold) m specialized epithelial cells collecting antigen. Allergy = immune response directed to noninfectious antigen. Autoimmunity = immune response is directed towards a self antigen. Graft rejection = antigen is introduced by a transplanted foreign cell: acute phase/infection, 2) clinically latent phase, 3) aids. Aids marked depletion in cd4+ lymphocytes: acute phase = 1000 500 t cell/um, clinically latent phase 499-200 tcell/um, aids lower than 200 tcell/um. A asymptomatic, acute hiv, or persistent lymphadonepathy. Other than those phases, theres also a b and c. Aids = opportunistic infections and tissue-specific hiv associated diseases. Aids-dementia complex = lose your mind (by infected microglia) Opportunistic infections (adult = fungi) (kids = bacteria)
