NSCI 1413 Lecture Notes - Lecture 13: Myelin, Immunoglobulin G, Retrovirus
6 May 2017
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First line of defense: barriers, preventing pathogens from entering the body. Cilia (sweep out microbes trapped in mucous) Second line of defense: limits speed of invaders. Prostaglandins: further promote blood flow to the area. Chemokines: secreted by blood vessel endothelium and monocytes also attract phagocytes to the area. Pyrogens: released by certain leukocytes; body temp to speed up immune function (making it more. Phagocytes: ingest invading microbes; neutrophils and monocytes migrate to infected site in response to local difficult for microbes to function) chemical attractants (called chemotaxis) Monocytes transform into microphages, extend pseudopods, and engulf many microbes; digest microbes w/ a combination of lysozyme and two toxic forms of oxygen (o 2 . Complement: group of proteins that lead to lysis (bursting) of invading cells. Natural killer (nk) cells: destroy virus-infected body cells and cancer cells by attacking the cell membrane, causing lyse.
