BIOL 115 Lecture Notes - Lecture 23: Genetic Variation, Activation Energy, Chromosome

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31 Aug 2020
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Analyse information from a secondary source to outline the evidence that led to beadle and tatum"s one gene-one protein" hypothesis and explain why this was altered to one gene-one polypeptide" hypothesis. Beadle and tatum studied bread mould mutations brought about by x-rays, known as mutants. Further experimentation showed that some mutants could no longer produce essential amino acids (implying that an enzyme was no longer functioning). To test whether this loss of function has genetic basis, they crossed these mutant mould with normal mould and found that some of their offspring shared the mutant phenotype, proving that the amino acid could inherited. With further analysis it was found that different enzymes in different mutants had been altered or were missing, proving that a gene determines the structure of a specific enzyme. This lead to the first theory of one gene-one protein". Once it was demonstrated that there are other proteins beside enzymes that are encoded by genes.

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