BIOL 121 Lecture Notes - Lecture 21: Colloid, Podocyte, Vise

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16 Dec 2020
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All blood that is directed to the kidneys does not get filtered into bowman"s space. Limited surface area for filtration due to podocytes slit size allows only 20% of blood flow to the glomerulus to be filtered into bowman"s space. The blood that does not enter bowman"s space exits the glomerulus via the efferent arteriole and eventually exits the kidney returning to main circulation. Combination of forces affect the amount of plasma that is filtered into bowman"s space; these forces create net filtration pressure. Net filtration pressure = +, filtration can occur. Net filtration pressure= 0/-, filtration will not occur. Pressures affecting glomerular filtration: hydrostatic pressure of glomerular capillaries (pgc) Pressure caused by blood flowing into the glomerulus. Value of 55mmhg: colloid osmotic pressure of glomerular capillaries ( gc) Pressure caused by the presence of proteins in the glomerulus. Value of 30mmhg: hydrostatic pressure of bowman"s capsule (pbc) Pressure caused by the filtrate remaining in bowman"s space.

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