BIOL 123 Lecture Notes - Lecture 15: Intermediate Frequency, Alcohol Dehydrogenase, Exon
Document Summary
Natural selection eliminates, substitutes, and maintains specific molecular genetic variants. Occasionally beneficial mutations appear as a single copy, due to accidents for the individual that produces the gamete with the mutation. Don"t sweep 100%, but sweep to an intermediate frequency, but. It is uncertain how much nucleotide evolution is due to selection, but there is some many then will appear as mutants again, and establishes a population evidence for selection on particular nucleotides. Before dna was sequenced, we had the ability to sequence proteins. 1980s: technique to separate protein by size and charge. Organism is put into a buffer and gel with a solution that can conduct electricity, making a gradient of +/- electrodes, making the proteins have a positive change, and pulled to the negative electrode. The distance they traveled through the gel showed the function of how big the protein is and how big the charge is.
