BIOL 117 Lecture Notes - Lecture 7: Central Dogma Of Molecular Biology, Phenotype, Francis Crick
Document Summary
What do genes do: carry the instructions for making and maintaining an individual, gene expression= translating info in dna into functioning molecules within the cell. Beadle and tatum would damage genes and see what would happen to the phenotypes of the subjects afterwards: called a knockout strategy. Srb and horowitz = one-gene, one-enzyme hypothesis: there are metabolic pathways that eventually lead to the resulting nal product, each gene contains info to create the enzymes needed for the pathway. The central dogma of molecular biology: genes ultimately code of protein. Jacob and monod proposed that rna links genes in the nucleus with the outside of the nucleus. Rna polymerase and mrna: transcription and translation/flow of information. Dna is transcribed to mrna by rna polymerase. When transcribed mrna is used to create amino acids and proteins= translation: genotype= sequences in the bases of dna, phenotype= product of the protein produced in the organism, exceptions.
