BIOL 222 Lecture 34: Genetics in Medicine
3 Dec 2016
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Extra credit due that day too: nal exam review materials to be posted soon. Genetics in medicine - outline: how do we determine if there is genetic basis for disease, how to use haploid genotypes to identify disease alleles. Diseases inherited in a mendelian fashion: omim. org. Relatives more likely to have that disease compared to non-relatives. Correlation between disease and changes in dna sequence or chromosome structure. Disease in humans resembles disease in animals. Inheritance of a disease does not always follow mendel"s rules: locus heterogeneity. Disease can be caused by mutations in two or more different genes: same disease can be caused by different gene mutations. Inheritance of disease does not aways follow mendel"s rule: complex traits. Intelligence: interplay between environment and genetics. How do geneticists study disease inheritance: ex. using haplotypes to identify disease alleles. Nd known variants (haplotypes) that are spaced throughout the genome. Look for linkage of these haplotypes to disease phenotype.
