CHEM 211 Lecture Notes - Lecture 25: Endergonic Reaction, Lone Pair, Leaving Group
10 Nov 2016
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Document Summary
Alkyl halide: usually partially positive and partially neg. dipoles. Different kinds of organic halides: we can have primary, secondary, and tertiary. Sn1 stepwise reactions: need to be able to draw three steps, sometimes, because even after the second step there is still a charge, there must be a third step to make the charge go away. Nucleophiles: reagent that is a positive center, typically a lewis base (electron donor) of neutral or negative charge, usually has a lone pair. Leaving groups: usually to be a good leaving group, must be stable on your own, typically are weak bases, ots and oms are two created groups that are very good leaving groups. Rate of reaction for sn2: double the substrate, double the reaction, double the reactant, double the reaction, double both, quadruple the reaction. Stereochemistry for sn2: inversion of con guration. The slowest step in a reaction = the rate limiting step.
