BIOL 2344 Lecture Notes - Lecture 15: Liposome, Skeletal Muscle, Deoxyadenosine
26 Oct 2017
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Dolly: could be some sort of deprogramming when nucleus was placed into enucleated egg (even though the nucleus came from skin cell) must be something in environment of egg that controls potency. In theory, stem cells could be used to regenerate certain tissue types (neural, skin, cardiac, cartilage, bone, liver, skeletal muscle) Induced pluripotent stem cells (ips cells) ~ how to make totipotent cells from pluripotent. Introduction of cloned genes into living cells in an attempt to cure disease: has hit a stop since people are not sure we should be doing this, transferring methods, 1. Nonviral approach: liposome technique most common (small circular of fluids with lipids, 2. Viral approach: most common are retroviruses, adenoviruses and parvoviruses, retroviruses insert randomly since it inserts itself into cell , adenosine deaminase (ada) enzyme involved in purine metabolism.
