BIOL 4570 Lecture Notes - Lecture 2: Pattern Recognition Receptor, Complement System, Neutrophil
Document Summary
Constitutive innate induced innate - recruitment cells (neutrophils and macrophages phagocytic cells can recognize pathogens through pamps and prrs; induce inflammatory response) adaptive - b and. T cells recognize pathogens; clonal expansion and differentiation to effector cells. Prrs: pattern recognition receptors; have evolved since they enhance survival; recognize pamps. 4 types of sites where pathogens may invade. Viruses will begin outside of cell and will eventually make their way inside cell. Antimicrobial peptides part of innate; secreted by epithelial cells. Infected cells can be killed by induced innate nk cells or adaptive is cytotoxic t cells. Macrophages can be activated by helper t cells to induce microbicidal activities. Exotoxins take over vital functions of cells. Endotoxins produced when bacteria is killed; lps is most common (gram neg cell wall) Dendritic cells can be resident in tissues can be called sentinels; have prrs; can take in pathogen travel to lymph node launches adaptive is.
