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BIOL 4570 Lecture Notes - Lecture 9: Antigen-Presenting Cell, Antigen Presentation, Mhc Class I

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coralpanda603
27 Feb 2020
School
Georgia Tech
Department
Biology
Course
BIOL 4570
Professor
Jung Choi

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Document Summary

Immunology: class i vs class ii compare & contrast. Evasins block antigen presentation by preventing peptide movement through tap peptide transporter. E19 competes with tapasin and inhibits peptide loading onto mhc i proteins mk3 protein ubiquitinates mhc i degraded by proteasome. Calnexin stabilizes mhc i molecule when it is unbound to peptide. Calreticulin does same thing with help of erp57. Mhc ii pathway: antigen is taken up from ec space into intracellular vesicles. In early endosomes of neutral ph, endosomal proteases are inactive: acidification of vesicles activates proteases to degrade antigen into peptide fragments, vesicles containing peptides fuse with vesicles containing mhc class ii molecules, chaperones. Clip, bound to class ii molecule: clip fits almost all class mhc ii does not have great affinity because it is acting as place holder, sorted into specialized endosomal vesicles only in apcs. Golgi has class ii molecules associated with invariant chain, large diameter circles.

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Related Questions

Immunology worksheet help?

1. In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon?
A. TAP
B. Ii
C. TCR
D. CLIP
E. RAG
2. Your chances of having the same MHC haplotype as your siblingare:
A. 1:2.
B. 1:4.
C. 1:16.
D. 1:8.
E. 1:1.
3. Which of the following is the BEST example of self-MHCrestriction of T cells?
A. A T-cell clone is deleted when it binds too tightly to selfMHC.
B. A T-cell clone responds more vigorously to a self-peptide thana foreign peptide.
C. A T-cell clone recognizes foreign MHC.
D. A T-cell clone only recognizes foreign peptides when presentedby self MHC.
E. All of the above
4. MHC molecules:
A. are conserved between individuals.
B. bind repeating patterns found on pathogens.
C. are recognized by T cells.
D. are membrane-bound molecules found exclusively on T cells.
E. are secreted by T cells and bind and neutralize antigen in theserum.
5. Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this?
A. They would compensate for low diversity in the MHC with highdiversity in the TCR.
B. They would compensate for low diversity in the MHC with highdiversity in the BCR.
C. They would rely only on innate immune responses.
D. They would be at higher risk of infection.
E. All of the above
6. How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress?
A. Six
B. Two
C. Three
D. One
E. None. Only APC express class I.
7. MHC polymorphisms tend to cluster:
A. in the peptide-binding groove.
B. in the transmembrane domain.
C. in the coreceptor contact residues.
D. in the framework region.
E. All of the above
8. A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to:
A. cells with no class II MHC.
B. a deficiency in CD8+ T cells.
C. cells with class II MHC only bound with CLIP.
D. cells with class II MHC bound with a variety ofself-antigens.
E. cells with no DO.
9. The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean?
A. This region is regulated by many different mechanisms.
B. Sequence variability is low in this region.
C. There are many introns in this region.
D. There are many different alleles of these genes.
E. It has the most different genes.
10. Which of the following is an example ofcross-presentation?
A. An exogenous peptide being presented on MHC class II
B. A B-cell antigen being presented to a T cell
C. An endogenous peptide being presented on MHC class I
D. An endogenous peptide being presented on MHC class II
E. An exogenous peptide being presented on MHC class I