PSY 177 Lecture Notes - Lecture 8: Cannabis Sativa, Cerebrospinal Fluid, Substantia Nigra
27 Aug 2016
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Document Summary
Conditioned tolerance depends on environmental cues; environment elicits conditioned compensatory responses (opposite of the drug effects) Larger ventricles (spaces full of cerebral spinal fluid) in the brain (gross brain atrophy) which means less white & grey matter. Brain damage after many years of drinking often leads to skewed motivation & reward system and thus includes inadequate nutrition, particularly thiamine (vitamin b1) Leads to wernicke-korsakoff"s syndrome (memory loss, confabulation, sensory & motor dysfunction, and eventually dementia) Damage is believed to be in the medial thalamus and hypothalamus. Brain damage effects are largely reversible with extended abstinence. Endogenous opiates peptides produced in the body that bind to opioid receptors and relieve pain. Different ways to bind to receptors: agonist, partial agonist, antagonist. Morphine, codeine, meperidine (demerol ), oxycodone (percocet ), hydrocodone (vicodin ) Competes with higher efficacy drug; less risk of dependence and respiratory depression. Can actually combat agonist by knocking them off of receptors and blocking effects.
