NUR 239 Lecture Notes - Lecture 19: High-Density Lipoprotein, Peripheral Artery Disease, Coronary Artery Disease
21 May 2018
School
Department
Course
Professor
NUR 239/Pathophysiology and Pharmacotherapeutics in Nursing I
Unit 3/Dyslipidemia
Complete the following study guide and submit on Reggie Net by the due date on the Course Calendar
1
You should have an understanding of all the key terms at the beginning of each Chapter.
Key Learning Objectives - Answer the follow questions (Chapter 10 – Drug Therapy for Dyslipidemia):
▪ People with elevated blood lipid levels are at risk for what type of disorders?
o atherosclerosis, myocardial ischemia, MI, stroke, peripheral arterial occlusive disease
▪ What lifestyle changes are often considered the cornerstone interventions to manage dyslipidemia?
o Modification of total fat intake, managing cholesterol, calories, increase physical moderate-
intensity aerobic exercise to promote weight loss and cardiovascular health
▪ Do the lifestyle intervention work?
o If the intervention begins when you are a young child or infant, the process of keeping up with the
regimens become a normality.
o As an adolescent or adult, it is better to be consistent for a more positive outcome.
▪ Why are dyslipidemic drugs used?
o To alter the production, absorption, metabolism or removal of lipids and lipoproteins.
▪ Identify the components of the blood lipids, where each is primarily found, and their physiologic (normal)
purpose.
o HDL cholesterol
▪ Good cholesterol
▪ Synthesized in the liver and intestine
▪ contains amounts of cholesterol
• Transported from blood vessel walls to the liver for catabolism and excretion
• Protects against coronary heart disease
o LDL cholesterol:
▪ Bad cholesterol
▪ Transports serum cholesterol and carries it to the peripheral tissues and the liver
▪ removed from the circulation by receptor and nonreceptor mechanism
▪ Located in the liver
o VLDL Very low-density lipoprotein
▪ Describe the elements of Metabolic Syndrome.
o Central adiposity (increased waist circumference)
o Elevated triglycerides
o Reduced HDL cholesterol
find more resources at oneclass.com
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Document Summary
Complete the following study guide and submit on reggie net by the due date on the course calendar. You should have an understanding of all the key terms at the beginning of each chapter. Intake may have other beneficial vascular effects: for single-drug therapy, what drug class is preferred for the treatment of dyslipidemia, hmg-coa reductase inhibitors. Po admin: first pass metabolism by liver, peak 1-2 hours, food decreases rate and extent of absorption when taken orally, drug excreted in feces and essentially unchanged. Use: treatment of, reduces ldl hypercholesterolemi a and reducing cardiovascular events in people with multiple risk factors cholesterol levels and also produces a minimal elevation in. Adverse effects: nausea, cholestyramin, gi discomfort and constipation, e is not diarrhea diarrhea, abd cramps or pain, headache, skin rash, hepatic dysfunction, myopathies. Contraindication s: pregnant women and their lactation.
