AN S 345 Lecture Notes - Lecture 7: Muscle, Myf6, Myf5
6 Mar 2017
School
Department
Course
Professor
Document Summary
What"s the difference? red fibers = slow twitch white fibers = fast twitch. To form a primary myotube start with stem cells myoblast proliferation myotubes differentiated here and become multinucleated. G0 in the cell cycle - cell cycle arrest a prerequisite for myoblast fusion --> myotube committed to a specialized cell type. Myo d: blocks proliferation via cooperation with cell cycle ; going to be our cyclins and cyclin dependent kinases. Myogenin: initiated terminal differentiation ; the marker of differentiation. Mrf4 (myf-6): causes maturation of myotubes into mature muscle fibers. Myosin: the major structural proteins that wind up the fibers. If we wanna go from a myoblast to a myotube we need transcription factors. Increase in mrna and proteins --> mrna goes to ribosomes then goes to the aa and then gets transported by the trna"s to the cytoplasm. Changes in the proteins leads to the change in the phenotypes of the cells.
