BIO 11 Lecture Notes - Lecture 32: Monocyte, Heparin, Hematocrit
Document Summary
Emigration and phagocytosis of wbcs: neutrophils and macrophages migrate to injury site by chemotaxis (attracted by toxins produced by microbes and kinins from injured cells, phagocytose bacteria and debris. Eosinophil function leave capillaries, enter tissue fluid release histaminase and other enzymes that combat effects of inflammatory mediators in allergic reactions: phagocytose ag-ab complexes and combat parasitic worms, count suggests allergic reaction or parasitic infection. Monocyte function slower to arrive at infection site but arrive in larger numbers, destroy more microbes: enlarge and differentiate into wandering macrophages, clean up cellular debris and microbes following infection. Differential wbc count: wbc count indicates inflammation or infection, differential count (count of each type of wbc as % of total wbcs) indicates type of pathology (infection, poisoning, leukemia, chemotherapy, parasites or allergy reaction) Platelet (thrombocyte) anatomy: disc-shaped cellular fragments 2 - 4 m in diameter, no nucleus, normal count = 150,000 400,000 cells/mm3 of blood, when a platelet is activated it changes its shape.
