Bianchi burnout depression overlap: a review distinction remains conceptually fragile. Mostly involves dysfunctional adaptations of the brain systems that regulate adaptations to stress. Icd-10 criteria for neurasthenia have sometimes been used as diagnostic guideline for burnout: possibly replacing overlap by definitional overlap between burnout and neurasthenia ( is already distinguished from depression in icd-10) Are job-related vs. genetic factors discriminating burnout from depression? not really. Weird: often stronger link between depression and job-specific factors than between job-specific factors and burnout evidence inconsistent insufficient consideration of the heterogeneity of the spectrum of depressive disorders. Oosterolt burnout and cortisol: evidence for a lower cortisol awakening response in. 30 min after awakening car both burnout groups lower compared to control non-clinical groups smaller decline of cortisol during the day relatively high cortisol on the evening. Vrshek the cortisol awakening response predicts major depression: a predictive stability. Over a 4 -year follow-up and effect of depression history.