CINEMA 3 Lecture Notes - Lecture 26: Oxidative Phosphorylation, Endoplasmic Reticulum, Calcification
Document Summary
In general, adult skin wound healing occurs in three overlapping phases. > wound healing proceeds similarly in muscle tissue. Fetal wound healing of the skin can occur without scar tissue forming. In the fetus, rapid wound closure is induced without scab formation and inflammation and with specific cytokine levels. > additionally, matrix deposition is rapid and similar to the uninjured fetal skin, whereas the extracellular is rich in hyaluronic acid. In diaphragmatic wounds, muscle regeneration is absent, and scar tissue forms. Similar to the healing of adult skin, the healing of adult muscle injury caused by trauma occurs in three overlapping phases. After muscle injury, disruption of myofiber plasma membrane initiates an influx of extracellular calcium, leading to calcium-dependent proteolysis. > results in necrosis and degeneration of damaged myofibers, which is restricted to the damaged site through the formation of a contraction band that seals off the defect.
