DANCEST 805 Lecture Notes - Lecture 37: Traf6, Hydrolysis, Apoptosis
Document Summary
The complement system: a system of soluble pattern-recognition receptors and effector molecules that detect and destroy microbes made of three main groups that initiate response and leads to an amplification cascade; these activate the system: c1q (classical pathway) Interacts with an antibody coated pathogen surface: mannose-binding lectin (mbl) and ficolins (lectin pathway, recognize carbohydrates on pathogen surfaces, c3 (alternative pathway) It undergoes spontaneous hydrolysis leading to deposition of c3 convertase on pathogen surface. The complement helps antibodies and phagocytes clear microbes from an organism in three ways: Chemotaxis: some complement proteins act as chemoattractants to recruit more phagocytes to the site of complement activation. Pathogen lysis: complement components damage certain bacteria by creating pores in the bacterial membrane. Clq protein binds an antibody fc domain and becomes activated. Activation of the c3 convertase is the key event in complement activation. Associated molecular patterns (pamps) are recognised by a small number of pattern.
