MARKET 1 Lecture Notes - Lecture 2: Angiotensin-Converting Enzyme, Vascular Smooth Muscle, Unstable Angina
Document Summary
Beta-blockers: bisoprolol, propranolol, atenolol, stable & unstable angina, resistant hypertension. Potassium channel activators: nicorandil, hyperpolarisation of vascular smooth muscle (arterial & venous dilator, headaches, flushing, dizziness, angina symptomatic despite treatment. Inhibits f-type na+ channels in heart: reduces cardiac pacemaker ability in heart (slows hr) Thiazide-like diuretics: note effective in severe renal impairment. Distal convoluted tubule, inhibit sodium reabsorption (contraindicated in diabetes can increase blood sugar) Side effects thiazide-like diuretics hypokalemia, hyponatraemia, gout, impotence monitor for dehydration ineffective in moderate to severe renal impairment (gfr<30mls/min) High-dose loop diuretics: used in raised bp in renal failure. Sns antagonists: b-blockers, alpha-1 adrenoreceptor blocker (block vasoconstriction, doxazosin. Kidney function modifiers: potassium sparring diuretics, amiloride, aldosterone antagonists, spironolactone (collecting duct) (inhibit sodium reabsorption by inhibiting aldosterone, side effects - hyperkalaemia, renal impairment, gi upset, spironolactone oestrogen related side-effects. Inhibits ap propagation -> rate of cardiac depol at phase 0.
