PHYSICS 102 Lecture Notes - Lecture 16: Lysosome, P53, Epistasis
Document Summary
Basic introduction to cell proliferation and cell death sdl. Define the terms cancer, neoplasia, tumour, mutagenesis and oncogenesis. Cancer: disease caused by uncontrolled division of abnormal cells. Tumour: swelling of part of the body due to abnormal growth of tissue. Explain the importance of the loss of cell cycle control in neoplasia. This is because the express telomerase (which reverses the wearing down of chromosome ends that normally happen during each cell division): oncogenes: positive cell cycle regulators that may be overactive in cancer. In cancer cells, negative regulators of the cell cycle (such as tumour suppressor genes) may be less active or nonfunctional. Describe histology images of different types of neoplasia. Histological appearance: symmetrical shape of tumour, clear border between it and surrounding tissue. Histological appearance: asymmetrical shape, uneven border between tumours and surrounding tissue. Necrosis: lethal cell injury or accidental cell death. Delineate the characteristics difference between apoptosis and necrosis.
