POL SCI 2 Lecture 13:
Document Summary
Bigler: structural image analysis of the brain in neuropsychology using magnetic. Clinically define pathology (e. g. degree or presence of atrophy or gross lesion localization) Coarsely identify lateralized lesions or abnormalities, but subcortical structures were difficult to differentiate & not sensitive to most subtle pathologies. 1980s: spect, pet and mr technology approached gross anatomy. Last decade of 20th century: neuroimaging started to become integral part of neuropsychological studies: but any type of quantitative image analysis had to be done by hand. Last decade and half shows accelerated number of neuroimaging-neuropsychology investigations. Aim: how quantitative neuroimaging analysis methods are used to develop relevant metrics for neuropsychology. 1980s: ct or mri merely used to compare and contrast patients with identifiable pathology. Lesion overlap methods provide some quasi-quantitative indications of damage. Computer graphical analysis calculation of lesion volume = beginning of computational methods for quantitative neuroimaging. Voxel-based lesion-symptom mapping: exploring relations between focal lesion to neuropsychological function (figure 3)
