THEATER 335 Lecture Notes - Lecture 5: Anorectic, Skeletal Muscle, Impaired Glucose Tolerance
Document Summary
Hormonal and hypothalamic regulation of body fat and feeding. The idea that the brain monitors the amount of body fat and acts to defend this energy store against perturbations is called the lipostatic hypothesis. The hormone leptin, released by adipocytes (fat cells), regulates body mass by acting directly on neurons of the hypothalamus that decrease appetite and increase energy expenditure. Lesions mode on both sides of a rat"s hypothalamus can have large effects on feeding behavior and adiposity: bilateral lesions of the lateral hypothalamus caused anorexia. 2: the body"s integrated response to excessive adiposity, high leptin levels, and activation of the. Ghrelin: the peptide is highly concentrated in the stomach and is released into the bloodstream when the stomach is empty. Intravenous administration of ghrelin strongly stimulates appetite and food consumption by activating the npy/agrp-containing neurons of the arcuate nucleus. Insulin released into the bloodstream by the cells of the pancreas.
