NRS 150 Lecture Notes - Lecture 20: Diastolic Heart Failure, Heart Failure, Peripheral Edema

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Drugs for heart failure (chf, congestive heart failure) Two major forms of heart failure: heart failure (hf) with left ventricular (lv) systolic dysfunction, diastolic heart failure, also known as heart failure with preserved lv ejection fraction. Note: in this chapter, we focus primarily on the treatment of form #1. *characterized by left ventricular dysfunction, reduced cardiac output, insu cient tissue perfusion, and signs of uid retention. Was referred to as chf because hf frequently causes. Uid accumulation (congestion) in the lungs and peripheral tissue. Pathophysiology of heart failure: a syndrome in which the heart is unable to pump su cient blood to meet metabolic need of the tissue. Syndrome is characterized by signs of inadequate tissue perfusion (fatigue, sob, exercise intolerance) and/or signs of volume overload (venous distention, peripheral and pulmonary edema) **major underlying cause of hf are chronic htn and mi** Other causes: valvular heart disease, cad, congenital heart disease, dysrhythmias, and aging of the myocardium.

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