BISC 320 Lecture Notes - Lecture 23: Naked Mole-Rat, Basal Metabolic Rate, Anaerobic Glycolysis

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When the bonds are broken, that energy can be used to drive chemical reactions: production of atp, many tissues can produce atp anaerobically. To utilize this pathway, the tissue must express lactate dehydrogenase, which converts pyruvic acid to lactic acid. This high co2 concentration makes the air so acidic that it would make our eyes water and our skin burn. 50% can survive for 24 minutes with no oxygen. With the regular mice and humans, we can survive for a bit by producing glucose anaerobically. This causes a buildup of lactate that inhibits the first step of glycolysis. Atp production stops and the cells begin to die. In anoxygenic conditions, naked mole rats switch to using fructose to produce atp, a process that can be done without using oxygen and without the buildup of byproducts like lactate. Researchers used a patch clamp on the hippocampus to determine the effect of glucose and fructose on the ability to produce.

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