BISC 464 Lecture Notes - Lecture 3: Granulocyte, Mast Cell, Kallikrein
31 Oct 2017
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Document Summary
Inflammation- reaction to vascularized living tissue to local injury. 4 cardinal signs of inflammation: a. b. c. d. e. Chronic: greater than 48 hours (can be weeks, months, or years) Chronic inflammation: mononuclear cells (macrophages, lymphocytes, plasma cells) Changes in vascular flow and caliber (hemodynamic changes) a. Histamine comes from mast cells (previously basophils in circulation) Outpouring of albumin rich fluid into the extravascular tissues (produces swelling) Slowing of circulation and packing of rbcs in capillaries causes hyperemia d. Neutrophils become oriented at the periphery of vessels and start to stick. Eventually they extravasate paste vessel wall and into tissue. Hyperemia in lung capillaries--packed with rbcs a. b. Edema: an excess of fluid in the interstitial tissue or serous cavities--either a transudate or an exudate. Exponentially multiplies and produces huge numbers of cells rapidly. C5a- chemotaxis; brings lots of white blood cells i. Also know c3a- opsonin; sticks to bacteria and marks it for phagocytic cells ii. iii. iv.
