BIOL 1201 Lecture Notes - Lecture 6: Blood Sugar, Cardiac Muscle, Cell Junction
28 Nov 2016
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Document Summary
Importance of signaling mechanisms: nobel prizes; 5 in the last 20 years, area where information is still changing. Direct contact: local: paracrine and synaptic signals, distant: hormonal signals (endocrine system) Don"t touch each other: figure 11. 4. Cell junctions and cell-cell recognition for local. Signal molecule and receptor: signal molecule binds to receptor. Receptors are highly specific and are all made out of proteins: transduction. G protein-coupled receptor attracts g protein which causes release of gdp when binded. Signal molecule binds to this receptor at same time, but never enters cell. (causes change in g-protein to become active) Signal molecule detaches and active g-protein moves to inactive receptor and activates it. Once they bind signal molecules, they come together and form a dimer which activates it. Add phosphate groups and then are used to activate other proteins. Have gate that open and closes channels. Signal molecule binds to this and opens gate and allows ions to come in.
